{"id":262,"date":"2023-06-21T11:36:29","date_gmt":"2023-06-21T03:36:29","guid":{"rendered":"https:\/\/cn.lianmiaopack.com\/?p=262"},"modified":"2023-06-28T22:13:19","modified_gmt":"2023-06-28T14:13:19","slug":"building-your-personal-brand","status":"publish","type":"post","link":"https:\/\/www.dbpharm.net\/index.php\/2023\/06\/21\/building-your-personal-brand\/","title":{"rendered":"PD-(L)1\u5e02\u573a\u7684\u51b0\u4e0e\u706b\u4e4b\u6b4c"},"content":{"rendered":"<blockquote><p>\u5728\u521b\u65b0\u836f\u7684\u4e16\u754c\u91cc\uff0cPD-(L)1\u836f\u7269\u582a\u79f0\u73b0\u8c61\u7ea7\u4ea7\u54c1\u3002\u5b83\u901a\u8fc7\u6291\u5236\u80bf\u7624\u514d\u75ab\u9003\u9038\u673a\u5236\u98a0\u8986\u4f20\u7edf\u80bf\u7624\u6cbb\u7597\u8303\u5f0f\uff0c\u4e0d\u4ec5\u9769\u65b0\u4e86\u80ba\u764c\u3001\u809d\u764c\u548c\u80c3\u764c\u7b49\u5e38\u89c1\u764c\u79cd\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u4e5f\u586b\u8865\u4e86Merkel\u7ec6\u80de\u7624\u548c\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\u7b49\u7f55\u89c1\u7624<\/p><\/blockquote>\n<div>\n<p>\u5728\u521b\u65b0\u836f\u7684\u4e16\u754c\u91cc\uff0cPD-(L)1\u836f\u7269\u582a\u79f0\u73b0\u8c61\u7ea7\u4ea7\u54c1\u3002\u5b83\u901a\u8fc7\u6291\u5236\u80bf\u7624<a href=\"https:\/\/www.medsci.cn\/guideline\/search?keyword=%E5%85%8D%E7%96%AB\">\u514d\u75ab<\/a>\u9003\u9038\u673a\u5236\u98a0\u8986\u4f20\u7edf\u80bf\u7624\u6cbb\u7597\u8303\u5f0f\uff0c\u4e0d\u4ec5\u9769\u65b0\u4e86<a href=\"https:\/\/www.medsci.cn\/search?q=%E8%82%BA%E7%99%8C&amp;sort_type=1&amp;search_type=1&amp;page=1\">\u80ba\u764c<\/a>\u3001<a href=\"https:\/\/www.medsci.cn\/topic\/show?id=370d8126914\">\u809d\u764c<\/a>\u548c<a href=\"https:\/\/www.medsci.cn\/guideline\/search?keyword=%E8%83%83%E7%99%8C\">\u80c3\u764c<\/a>\u7b49\u5e38\u89c1\u764c\u79cd\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u4e5f\u586b\u8865\u4e86Merkel\u7ec6\u80de\u7624\u548c\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\u7b49\u7f55\u89c1\u7624\u79cd\u7684\u6cbb\u7597\u7a7a\u767d\u3002\u5e7f\u8c31\u7684\u6297\u80bf\u7624\u6548\u5e94\u4e0e\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u9a71\u52a8\u4e0b\uff0cPD-(L)1\u5e02\u573a\u7a7a\u95f4\u968f\u4e4b\u6253\u5f00\u3002<\/p>\n<p>2022\u5e74\uff0c\u5168\u7403PD-(L)1\u5e02\u573a\u89c4\u6a21\u7ea6387.64\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f19%\u3002\u8fd9\u4e5f\u662fPD-(L)1\u5e02\u573a\u6301\u7eed\u6269\u5f20\u7684\u7b2c8\u4e2a\u5e74\u5934\u30022015\u5e74\uff0cPD-(L)1\u5e02\u573a\u4ec5\u6709\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u548c\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u5792\uff0c\u4e24\u8005\u9500\u552e\u989d\u5408\u8ba1\u7ea615.48\u4ebf\u7f8e\u5143\u3002\u4e4b\u540e\uff0c\u963f\u66ff\u5229\u73e0\u5355\u6297\u548c\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u7b49\u76f8\u7ee7\u5165\u5c40\uff0cPD-(L)1\u5e02\u573a\u5206\u522b\u57282018\u5e74\u30012019\u5e74\u548c2021\u5e74\u8de8\u8d8a100\u4ebf\u3001200\u4ebf\u548c300\u4ebf\u7f8e\u5143\u95e8\u69db\u3002\u53d1\u5c55\u81f3\u4eca\uff0c\u5168\u7403\u5df2\u670922\u6b3ePD-(L)1\u6297\u4f53\uff08\u5305\u62ec\u53cc\u6297\uff09\u83b7\u6279\u4e0a\u5e02\uff0cPD-(L)1\u5e02\u573a\u4fe8\u7136\u662f\u4e00\u7247\u7ea2\u6d77\uff0c\u968f\u7740\u5e02\u573a\u9971\u548c\u5ea6\u7684\u5347\u9ad8\uff0c\u5176\u589e\u901f\u4e5f\u9010\u5e74\u56de\u843d\u3002<\/p>\n<p>\u5168\u7403\u4e0a\u5e02\u7684PD-(L)1\u6297\u4f53\u4e2d\uff0c\u56fd\u4ea7\u529b\u91cf\u5360\u636e\u534a\u58c1\u6c5f\u5c71\uff0c\u8fbe\u523012\u6b3e\u4e4b\u591a\u3002\u57282015\u5e74\u836f\u653f\u6539\u9769\u548c\u8d44\u672c\u52a9\u63a8\u4e0b\uff0c\u4ee5\u541b\u5b9e\u3001\u4fe1\u8fbe\u3001\u6052\u745e\u548c\u767e\u6d4e\u795e\u5dde\u4e3a\u4ee3\u8868\u7684\u56fd\u5185\u836f\u4f01\u8fc5\u901f\u63a8\u51fa\u65d7\u4e0bPD-(L)1\u4ea7\u54c1\uff0c\u5f7c\u65f6\u4e00\u6d3e\u6b23\u6b23\u5411\u8363\u7684\u666f\u8c61\u4f7f\u5f97\u4e0d\u5c11\u4e1a\u5185\u4eba\u58eb\u5bf9PD-(L)1\u5e02\u573a\u5bc4\u4e88\u5343\u4ebf\u671f\u8bb8\u3002<\/p>\n<p>\u7136\u800c\uff0c\u56fd\u5185\u836f\u4f01\u7684\u540c\u8d28\u5316\u5185\u5377\u5bfc\u81f4PD-(L)1\u9677\u5165\u4ef7\u683c\u93d6\u6218\uff0c\u53c8\u9762\u4e34\u533b\u4fdd\u8c08\u5224\u7684\u964d\u4ef7\u538b\u529b\uff0c\u4f7f\u5f97PD-(L)1\u5e02\u573a\u5343\u4ebf\u7684\u60f3\u8c61\u7a7a\u95f4\u574d\u584c\u3002\u6839\u636e\u56fd\u5185\u5df2\u516c\u5e03\u7684\u8d22\u62a5\u4fe1\u606f\uff0c2022\u5e74\u56fd\u4ea7PD-(L)1\u6297\u4f53\u7684\u5e02\u573a\u4f53\u91cf\u7ea6\u4e3a75.77\u4ebf\u5143\u4eba\u6c11\u5e01\uff08\u7ea6\u540811.27\u4ebf\u7f8e\u5143\uff09\uff0c\u82e5\u7b97\u4e0a\u5361\u745e\u5229\u73e0\u5355\u6297\u6216\u7834\u767e\u4ebf\u5143\uff0c\u4f46\u4e5f\u53ea\u5360\u636e\u5168\u7403\u5e02\u573a3%-4%\u7684\u4efd\u989d\u3002<\/p>\n<p>\u6ce1\u6cab\u7834\u88c2\u7684\u540c\u65f6\uff0c\u56fd\u5185PD-(L)1\u5e02\u573a\u4e5f\u840c\u751f\u4e86\u65b0\u7684\u53d8\u5316\u2014\u2014\u6d3e\u5b89\u666e\u5229\u5355\u6297\u3001\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u548c\u6069\u6c83\u5229\u5355\u62972022\u5e74\u8425\u6536\u8d855\u4ebf\u5143\uff0c\u65af\u9c81\u5229\u5355\u6297\u57282023Q1\u7a81\u78342.5\u4ebf\u5143\u3002\u8fd9\u4e9b\u533b\u4fdd\u76ee\u5f55\u5916\u7684PD-(L)1\u4ea7\u54c1\u6216\u51ed\u501f\u5353\u8d8a\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\uff0c\u53c8\u6216\u501a\u4ed7\u83b7\u6279\u9002\u5e94\u75c7\u7684\u72ec\u7279\u6027\uff0c\u6291\u6216\u4f9d\u9760\u66f4\u4e3a\u4fbf\u6377\u7684\u7ed9\u836f\u4f18\u52bf\uff0c\u6b63\u5f90\u5f90\u6495\u5f00\u81ea\u8d39\u5e02\u573a\u7684\u53e3\u5b50\uff0c\u4e3a\u4e2d\u56fd\u521b\u65b0\u836f\u7684\u5e02\u573a\u51c6\u5165\u63cf\u7ed8\u66f4\u591a\u53ef\u80fd\u6027\u2026\u2026<\/p>\n<p>\u6ca1\u6709\u7ec8\u70b9\u7684\u5e02\u573a\u53ae\u6740<\/p>\n<p>\u5927\u5bb6\u5df2\u7ecf\u8fbe\u6210\u4e00\u4e2a<a href=\"https:\/\/www.medsci.cn\/guideline\/list.do?q=%E5%85%B1%E8%AF%86\">\u5171\u8bc6<\/a>\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u3001\u963f\u66ff\u5229\u73e0\u5355\u6297\u548c\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8fd94\u6b3e\u5934\u90e8\u4ea7\u54c1\u5206\u8d70PD-(L)1\u5e02\u573a\u7684\u7edd\u5927\u90e8\u5206\u86cb\u7cd5\u3002\u6570\u636e<a href=\"https:\/\/www.medsci.cn\/search?q=%E7%BB%9F%E8%AE%A1\">\u7edf\u8ba1<\/a>\u4e5f\u786e\u5b9e\u5982\u6b64\uff0c2022\u5e74\u8fd94\u6b3e\u5355\u6297\u5408\u8ba1\u5305\u63fd94%\u7684\u5168\u7403\u5e02\u573a\u4efd\u989d\u3002\u5176\u4e2d\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\u51ed\u501f\u5927\u57fa\u6570\u9ad8\u589e\u957f\u6001\u52bf\u5b9e\u73b0\u5e02\u573a\u4efd\u989d\u7684\u8fde\u5e74\u6269\u589e\uff0c\u5176\u4f593\u6b3ePD-(L)1\u5355\u6297\u5747\u663e\u793a\u4e0d\u540c\u7a0b\u5ea6\u7684\u4efd\u989d\u6536\u7f29\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u57282023Q1\u4ee550%\u7684\u5f3a\u52b2\u589e\u52bf\u51e0\u4e4e\u8ffd\u5e73\u4e86\u4e0e\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e4b\u95f4\u7684\u5dee\u8ddd\u3002<\/p>\n<p>\u5f53\u5934\u90e8\u4ea7\u54c1\u51e0\u4e4e\u5784\u65ad\u5e02\u573a\uff0c\u65b0\u52bf\u529b\u6e90\u6e90\u4e0d\u65ad\u6d8c\u5165\uff0cPD-(L)1\u5e02\u573a\u7684\u672b\u4f4d\u7ade\u4e89\u5c31\u53d8\u5f97\u5c24\u4e3a\u6fc0\u70c8\u3002\u56fd\u5185\u53c2\u8d5b\u9009\u624b\u4e2d\uff0c\u6700\u65e9\u4e0a\u5e02\u7684\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u9500\u552e\u4e1a\u7ee9\u5448\u73b0\u8f83\u5927\u6ce2\u52a8\uff0c\u5148\u662f\u4ece2020\u5e74\u768410.03\u4ebf\u5143\u9ad8\u5cf0\u8170\u65a9\u4e3a2021\u5e74\u76844.12\u4ebf\u5143\uff0c2022\u5e74\u53c8\u56de\u5347\u81f37.36\u4ebf\u5143\uff0c\u9500\u552e\u91cf\u540c\u6bd4\u589e\u957f45%\u3002\u9500\u552e\u56de\u6e29\u56fa\u7136\u662f\u4e00\u4e2a\u597d\u7684\u4fe1\u53f7\uff0c\u4f46\u4ece2022\u5e74\u56fd\u5185PD-(L)1\u5e02\u573a\u4efd\u989d\uff08\u4e0d\u5305\u62ec\u5361\u745e\u5229\u73e0\u5355\u6297\uff09\u6765\u770b\uff0c\u62e5\u6709\u5148\u53d1\u4f18\u52bf\u7684\u7279\u745e\u666e\u5229\u5355\u6297\u4ec5\u5360\u6bd410%\uff0c\u8ddd\u79bb\u7ad9\u7a33\u811a\u8ddf\u8fd8\u6709\u5f88\u957f\u4e00\u6bb5\u8def\u8981\u8d70\u3002<\/p>\n<p>\u5728\u5df2\u62ab\u9732\u9500\u552e\u989d\u7684PD-(L)1\u6297\u4f53\u4e2d\uff0c<a href=\"https:\/\/www.medsci.cn\/topic\/show?id=329c2e376fa\">\u4fe1\u8fea\u5229\u5355\u6297<\/a>\u6210\u4e862022\u5e74\u552f\u4e00\u4e0b\u6ed1\u7684\u4e00\u6b3e\uff0c\u5176\u9500\u552e\u989d\u540c\u6bd4\u4e0b\u964d30%\u81f32.93\u4ebf\u7f8e\u5143\uff08\u7ea6\u540819.71\u4ebf\u5143\u4eba\u6c11\u5e01\uff09\uff0c\u5728\u56fd\u5185PD-(L)1\u5e02\u573a\u7684\u4efd\u989d\u66f4\u662f\u75312021\u5e74\u768454%\u9510\u51cf\u4e3a2022\u5e74\u768426%\u3002\u4fe1\u8fbe\u7684\u5408\u4f5c\u4f19\u4f34\u793c\u6765\u5c06\u4fe1\u8fea\u5229\u5355\u6297\u7684\u4e1a\u7ee9\u4e0d\u4f73\u5f52\u56e0\u4e8e\u533b\u4fdd\u8c08\u5224\u3001\u7ade\u4e89\u503e\u8f67\u548c\u65b0\u51a0\u75ab\u60c5\u4e09\u65b9\u538b\u529b\u3002\u4fe1\u8fea\u5229\u5355\u62972023Q1\u7684\u9500\u552e\u6210\u7ee9\u4f9d\u7136\u4e0d\u7406\u60f3\uff0c\u8425\u65360.61\u4ebf\u7f8e\u5143\uff08\u7ea6\u54084.17\u4ebf\u5143\u4eba\u6c11\u5e01\uff09\uff0c\u964d\u5e45\u4e3a29%\u3002<\/p>\n<p>\u5361\u745e\u5229\u73e0\u5355\u6297\u7684\u5904\u5883\u540c\u6837\u4e0d\u5bb9\u4e50\u89c2\uff0c\u5b83\u57282021\u5e74\u5df2\u51fa\u73b0\u9500\u552e\u989d\u4e0b\u964d\u30022022\u5e74\uff0c\u6052\u745e\u4e00\u5982\u65e2\u5f80\u672a\u516c\u5e03\u5176\u9500\u552e\u989d\uff0c\u4f46\u63a8\u6d4b\u5927\u62b5\u9003\u8131\u4e0d\u4e86\u4e0b\u884c\u7684\u8d70\u52bf\u3002<\/p>\n<p>\u4e00\u65b9\u9762\uff0c\u4ece\u533b\u7597\u673a\u6784\u5b9e\u9645\u91c7\u8d2d\u91cf\u6765\u770b\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u653e\u91cf\u901f\u5ea6\u6bd4\u8f83\u7f13\u6162\uff0c\u75312021\u5e74\u768444.27\u4e07\u74f6\u589e\u957f6%\u81f32022\u5e74\u768446.74\u4e07\u74f6\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u57282022\u5e74\u6ca1\u6709\u5f00\u62d3\u65b0\u7684\u6cbb\u7597\u9886\u57df\uff0c\u800c\u7279\u745e\u666e\u5229\u5355\u6297\u3001\u4fe1\u8fea\u5229\u5355\u6297\u548c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7eb7\u7eb7\u65a9\u83b7\u65b0\u9002\u5e94\u75c7\u3002\u8eab\u5904PD-(L)1\u7ade\u6280\u573a\uff0c\u4e0d\u8fdb\u4fbf\u662f\u9000\u3002<\/p>\n<p>PD-1\u56db\u5c0f\u9f99\u4e2d\u6700\u665a\u4e0a\u5e02\u7684\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5219\u662f\u4e00\u8def\u9006\u88ad\uff0c\u5206\u522b\u57282020\u5e74\u548c2022\u5e74\u8d76\u8d85\u7279\u745e\u666e\u5229\u5355\u6297\u548c\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4ee54.23\u4ebf\u7f8e\u5143\uff08\u7ea6\u540828.43\u4ebf\u5143\u4eba\u6c11\u5e01\uff09\u9500\u552e\u989d\u548c10\u9879\u83b7\u6279\u9002\u5e94\u75c7\u5904\u4e8e\u9886\u5148\u4f4d\u7f6e\u3002\u57282023JPM\u62a5\u544a\u4e2d\uff0c\u767e\u6d4e\u795e\u5dde\u8868\u793a\u201c\u867d\u7136\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e0a\u5e02\u8f83\u665a\uff0c\u4f46\u6210\u529f\u5360\u9886\u4e86\u4e2d\u56fd\u5e02\u573a\u7b2c\u4e00\u7684\u4efd\u989d\u201d\u3002\u5f53\u7136\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8fd8\u9700\u8981\u8c28\u9632\u540e\u6765\u8005\u7684\u653b\u64c2\u3002<\/p>\n<p>\u5eb7\u65b9\u5df2\u53d1\u8d77\u653b\u52bf\uff0c\u65d7\u4e0bPD-1\u5355\u6297\u6d3e\u5b89\u666e\u5229\u5355\u62972022\u5e74\u521b\u65365.58\u4ebf\u5143\u3002\u5355\u5c31164%\u7684\u5e74\u5ea6\u540c\u6bd4\u589e\u957f\u7387\u800c\u8a00\uff0c\u6d3e\u5b89\u666e\u5229\u5355\u6297\u7684\u9500\u552e\u8868\u73b0\u79f0\u5f97\u4e0a\u4eae\u773c\u3002\u4f46\u662f\uff0c\u82e5\u5c06\u9500\u552e\u989d\u6309\u65f6\u95f4\u6bb5\u62c6\u89e3\uff0c\u53c8\u6709\u53e6\u4e00\u756a\u666f\u8c61\u30022021\u5e748\u6708\uff0c\u6d3e\u5b89\u666e\u5229\u5355\u6297\u4e0a\u5e02\uff0c4\u4e2a\u591a\u6708\u6536\u83b72.12\u4ebf\u5143\uff1b2022\u5e74\uff0c\u6d3e\u5b89\u666e\u5229\u5355\u6297\u4eceH1\u76842.97\u4ebf\u5143\u73af\u6bd4\u4e0b\u964d12%\u81f3H2\u76842.61\u4ebf\u5143\uff0c\u540e\u52b2\u7565\u663e\u4e0d\u8db3\u3002<\/p>\n<p>\u6d3e\u5b89\u666e\u5229\u5355\u6297\u6216\u8bb8\u53ea\u662f\u53cc\u6297\u9f99\u5934\u5eb7\u65b9\u7684\u5546\u4e1a\u5316\u6572\u95e8\u7816\uff0c2022\u5e746\u6708\u95ee\u4e16\u7684PD-1\/CTLA-4\u53cc\u6297\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u51dd\u805a\u7740\u5eb7\u65b9\u66f4\u591a\u5fc3\u8840\u3002\u77ed\u77ed\u534a\u5e74\u95f4\uff0c\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u521b\u65365.46\u4ebf\u5143\uff0c\u6ca1\u6709\u8f9c\u8d1f\u4e1a\u754c\u5bf9\u4e8e\u8fd9\u6b3e\u5168\u7403\u9996\u4e2a\u80bf\u7624\u53cc\u514d\u75ab\u68c0\u67e5\u70b9\u53cc\u6297\u7684\u671f\u5f85\u3002\u8fd9\u4e5f\u610f\u5473\u7740\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u5728\u4e0a\u5e02\u9996\u5e74\u5151\u73b010\u4ebf\u9500\u552e\u4e1a\u7ee9\u7684\u76ee\u6807\u57fa\u672c\u6ca1\u6709\u60ac\u5ff5\u3002<\/p>\n<p>\u4f5c\u4e3a\u56fd\u5185\u7b2c13\u6b3e\u4e0a\u5e02\u7684PD-(L)1\u5355\u6297\uff0c\u65af\u9c81\u5229\u5355\u6297\u975e\u4f46\u6ca1\u6709\u6df9\u6ca1\u5728\u767d\u70ed\u5316\u7684\u7ade\u4e89\u4e2d\uff0c\u53cd\u800c\u4ee5\u8d85\u9884\u671f\u7684\u9500\u552e\u6570\u636e\u60ca\u8273\u51fa\u7ebf\u30022022\u5e743\u6708\uff0c\u65af\u9c81\u5229\u5355\u6297\u4ee5MSI-H\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\u4e3a\u5207\u53e3\u6253\u5165\u5e02\u573a\uff0c9\u4e2a\u6708\u5185\u9500\u552e3.39\u4ebf\u5143\u3002\u5f97\u76ca\u4e8e\u4e24\u9879\u91cd\u78c5\u80ba\u764c\u9002\u5e94\u75c7\u83b7\u6279\uff0c\u65af\u9c81\u5229\u5355\u6297\u57282023Q1\u521b\u90202.50\u4ebf\u5143\u7684\u9500\u552e\u6210\u7ee9\uff0c3\u6708\u5355\u6708\u7684\u9500\u552e\u989d\u5df2\u8d851\u4ebf\u5143\u3002\u6309\u7167\u8fd9\u4e48\u5f3a\u608d\u7684\u589e\u957f\u52bf\u5934\uff0c\u5176\u5e74\u5ea6\u9500\u552e\u989d\u5c06\u8f7b\u677e\u7a81\u783410\u4ebf\u5143\u3002<\/p>\n<p>\u5728\u5eb7\u5b81\u6770\u745e\u3001\u601d\u8def\u8fea\u548c\u5148\u58f0\u836f\u4e1a\u7684\u8fde\u6a2a\u4e0b\uff0c\u5168\u7403\u9996\u4e2a\u76ae\u4e0b\u6ce8\u5c04PD-L1\u5355\u6297\u6069\u6c83\u5229\u5355\u62972022\u5e74\u8986\u76d6\u7ea62\u4e07\u60a3\u8005\uff0c\u5728\u9996\u4e2a\u5546\u4e1a\u5316\u5b8c\u6574\u5e74\u53d6\u5f975.67\u4ebf\u5143\u8425\u6536\uff0c\u672a\u6765\u6709\u671b\u51ed\u9760\u4fbf\u6377\u7684\u7ed9\u836f\u65b9\u5f0f\u548c\u65b0\u9002\u5e94\u75c7\u62d3\u5c55\u51b2\u51fb10\u4ebf\u5143\u5173\u5361\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u8fd8\u6709\u5609\u548c\u751f\u7269\u7684\u6770\u6d1b\u5229\u5355\u6297\u3001\u674e\u6c0f\u5927\u836f\u5382\u7684\u9996\u514b\u6ce8\u5229\u5355\u6297\u3001\u79d1\u4f26\u535a\u6cf0\u7684\u6cf0\u7279\u5229\u5355\u6297\u548c\u77f3\u836f\u7684\u6069\u6717\u82cf\u62dc\u5355\u6297\u5bf9PD-(L)1\u5e02\u573a\u864e\u89c6\u7708\u7708\uff0c\u6b63\u5728\u7b49\u5f85NMPA\u4e0a\u5e02\u6279\u51c6\u3002<\/p>\n<p>\u8fdb\u533b\u4fdd\u540e\u7684\u751f\u6b7b\u65f6\u901f<\/p>\n<p>\u533b\u4fdd\u51c6\u5165\u662f\u521b\u65b0\u836f\u63a8\u52a8\u5546\u4e1a\u5316\u843d\u5730\u7684\u91cd\u8981\u8def\u5f84\u4e4b\u4e00\uff0c\u662f\u5426\u8fdb\u5165\u533b\u4fdd\u4e5f\u6210\u4e3a\u836f\u4f01\u5fc5\u987b\u9762\u5bf9\u7684\u4e24\u96be\u6289\u62e9\u3002\u7eb3\u5165\u533b\u4fdd\u540e\u6709\u671b\u5b9e\u73b0\u7684\u5feb\u901f\u653e\u91cf\u56fa\u7136\u6781\u5177\u5438\u5f15\u529b\uff0c\u4f46\u731b\u70c8\u8df3\u6c34\u7684\u652f\u4ed8\u4ef7\u683c\u6781\u5927\u5730\u6324\u538b\u4e86\u521b\u65b0\u836f\u7684\u76c8\u5229\u7a7a\u95f4\uff0c\u4ee4\u5927\u6279\u836f\u4f01\u671b\u800c\u5374\u6b65\uff0c\u800c\u4e14\u8dfb\u8eab\u533b\u4fdd\u76ee\u5f55\u4e5f\u4e0d\u7b49\u4e8e\u8fdb\u9662\uff0c\u56e0\u6b64\u65e0\u6cd5\u4fdd\u8bc1\u533b\u4fdd\u51c6\u5165\u5e26\u6765\u7684\u9500\u91cf\u589e\u957f\u53ef\u4ee5\u5b8c\u5168\u6d88\u5f2d\u964d\u4ef7\u5f71\u54cd\u3002<\/p>\n<p>PD-(L)1\u5e02\u573a\u4e0a\uff0c\u7eb3\u5165\u533b\u4fdd\u7684\u4ea7\u54c1\u4ec5\u6709\u201c\u56db\u5c0f\u9f99\u201d\uff0c\u8fdb\u5165\u533b\u4fdd\u5bf9\u5176\u9500\u552e\u8868\u73b0\u4e5f\u662f\u5f71\u54cd\u4e0d\u4e00\u3002\u51ed\u501f\u5148\u9a71\u4f18\u52bf\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u5728\u8fdb\u5165\u533b\u4fdd\u9996\u5e74\u9500\u91cf\u6fc0\u589e\uff0c\u6b64\u540e\u9500\u552e\u66f2\u7ebf\u4e00\u8def\u4e0a\u626c\uff1b\u76f4\u52302021Q4\uff0c\u9500\u552e\u989d\u4e0b\u8dcc\u7684\u62d0\u70b9\u51fa\u73b0\uff0c\u793c\u6765\u5bf9\u6b64\u89e3\u91ca\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u9700\u6c42\u589e\u957f\u4e0d\u8db3\u4ee5\u62b5\u6d88\u533b\u4fdd\u964d\u4ef7\u7684\u8d1f\u9762\u5f71\u54cd\u3002\u7ecf\u8fc72022\u5e74\u533b\u4fdd\u8c08\u5224\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u533b\u4fdd\u652f\u4ed8\u4ef7\u683c\u4e0d\u53d8\uff0c\u4e3a1080\u5143\/100mg\uff0c\u5e76\u65b0\u589e\u4e00\u7ebf\u98df\u7ba1\u9cde\u764c\u548c\u4e00\u7ebf\u80c3\u764c\u4e24\u9879\u9002\u5e94\u75c7\u8fdb\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff0c\u5176\u4e2d\u4e00\u7ebf\u80c3\u764c\u662f\u5176\u4f59\u4e09\u5bb6\u8fd8\u672a\u80fd\u7eb3\u5165\u533b\u4fdd\u7684\u72ec\u5bb6\u9002\u5e94\u75c7\u3002<\/p>\n<p>\u7279\u745e\u666e\u5229\u5355\u6297\u7eb3\u5165\u533b\u4fdd\u540e\u7684\u9500\u552e\u8d70\u52bf\u6b63\u597d\u4e0e\u4fe1\u8fea\u5229\u5355\u6297\u76f8\u53cd\u3002\u7279\u745e\u666e\u5229\u5355\u6297\u6700\u521d\u4ee5\u8d8570%\u7684\u964d\u5e45\u6362\u53d6\u4e8c\u7ebf\u9ed1\u8272\u7d20\u7624\u5c0f\u9002\u5e94\u75c7\u7eb3\u5165\u533b\u4fdd\uff0c\u672a\u80fd\u5b9e\u73b0\u201c\u4ee5\u4ef7\u6362\u91cf\u201d\uff0c\u540c\u65f6\u56e0\u541b\u5b9e\u5546\u4e1a\u5316\u56e2\u961f\u9891\u7e41\u66f4\u8fed\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u57282021\u5e74\u9677\u5165\u9500\u552e\u4f4e\u8c37\u3002\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u533b\u4fdd\u4ef7\u683c\u4e3a1912.96\u5143\/240mg\uff0c\u5171\u67093\u9879\u9002\u5e94\u75c7\u7eb3\u5165\u533b\u4fdd\uff0c2022\u5e74\u83b7\u6279\u7684\u4e00\u7ebf\u98df\u7ba1\u9cde\u764c\u548c\u4e00\u7ebf\u975e\u9cde\u72b6<a href=\"https:\/\/www.medsci.cn\/topic\/show?id=2493130e1a1\">NSCLC<\/a>\u672a\u8fdb\u5165\u533b\u4fdd\u3002\u4e0e\u5176\u4ed63\u6b3ePD-1\u5355\u6297\u76f8\u6bd4\uff0c\u5176\u533b\u4fdd\u5185\u9002\u5e94\u75c7\u6700\u5c11\uff0c\u4e14\u9002\u7528\u4eba\u7fa4\u76f8\u5bf9\u72ed\u7a84\uff0c\u7ade\u4e89\u529b\u4e0d\u660e\u663e\u3002<\/p>\n<p>\u672a\u8fdb\u5165\u533b\u4fdd\u524d\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u5339\u914d\u6052\u745e\u5f3a\u5927\u7684\u9500\u552e\u7f51\u7edc\u951a\u5b9a\u9ad8\u4ef7\u8def\u7ebf\uff0c19800\u5143\/200mg\u7684\u521d\u59cb\u552e\u4ef7\u7ed3\u5408\u8d60\u836f\u65b9\u6848\u540e\uff0c\u5e74\u6cbb\u7597\u8d39\u7528\u7565\u9ad8\u4e8e\u5176\u4ed63\u6b3ePD-1\u5355\u6297\u3002\u4e00\u5957\u7ec4\u5408\u62f3\u6253\u4e0b\u6765\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u8fc8\u5411\u9500\u552e\u5dc5\u5cf0\u3002\u4e4b\u540e\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u6298\u4ef785%\u633a\u8fdb\u533b\u4fdd\u76ee\u5f55\uff0c\u7136\u800c\u653e\u91cf\u4e0d\u53ca\u9884\u671f\uff0c\u5bfc\u81f4\u51762021\u5e74\u9500\u552e\u6536\u5165\u540c\u6bd4\u4e0b\u964d\u3002\u5bf9\u6b64\uff0c\u6052\u745e\u79ef\u6781\u53c2\u4e0e2022\u5e74\u533b\u4fdd\u8c03\u6574\uff0c\u5c06\u5361\u745e\u5229\u73e0\u5355\u6297\u4ef7\u683c\u518d\u5ea6\u4e0b\u8c0312%\u81f32576.64\u5143\/200mg\uff0c\u6240\u7eb3\u5165\u7684\u9002\u5e94\u75c7\u6269\u5c55\u81f38\u9879\uff0c\u56ca\u62ec\u9f3b\u54bd\u764c\u548c\u98df\u7ba1\u9cde\u764c\u591a\u7ebf\u6cbb\u7597\u3002<\/p>\n<p>\u533b\u4fdd\u8c08\u5224\u7684\u5e38\u6001\u5316\u8fdb\u884c\uff0c\u5f71\u54cd\u7684\u4e0d\u5355\u5355\u662f\u67d0\u4e2a\u5355\u54c1\uff0c\u6052\u745e\u4ee5\u5f80\u5f3a\u52bf\u7684\u8425\u9500\u6a21\u5f0f\u4e5f\u9010\u6e10\u5931\u7075\u3002\u968f\u540e\uff0c\u6052\u745e\u5927\u5200\u9614\u65a7\u5730\u7cbe\u7b80\u9500\u552e\u56e2\u961f\uff0c\u5c06\u4eba\u5458\u6570\u76ee\u4ece2020\u5e74\u76841.7\u4e07\u524a\u51cf\u81f32022\u5e74\u76841\u4e07\u4eba\u3002\u5373\u4fbf\u5982\u6b64\uff0c\u5728\u5176\u4ed6\u521b\u65b0\u836f\u4f01\u51e0\u767e\u6216\u6570\u5343\u4eba\u4e0d\u7b49\u7684\u5546\u4e1a\u5316\u56e2\u961f\u9762\u524d\uff0c\u6052\u745e\u4e07\u4eba\u89c4\u6a21\u7684\u9500\u552e\u201c\u519b\u56e2\u201d\u4ecd\u6709\u50b2\u89c6\u7684\u8d44\u672c\u3002<\/p>\n<p>\u5c31\u73b0\u9636\u6bb5\u6765\u770b\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8fdb\u533b\u4fdd\u662f\u5229\u5927\u4e8e\u5f0a\u2014\u2014\u201c\u4ee5\u4ef7\u6362\u91cf\u201d\u6210\u6548\u7a81\u51fa\uff0c\u8fde\u7eed\u4e24\u5e74\u8fbe\u621050%\u4ee5\u4e0a\u7684\u9500\u552e\u589e\u957f\u3002\u901a\u8fc7\u65b0\u4e00\u8f6e\u56fd\u8c08\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4ef7\u683c\u8c03\u6574\u4e3a1377.5\u5143\/100mg\uff0c\u5728\u53bb\u5e74\u7684\u57fa\u7840\u4e0a\u964d\u4ef75%\uff1b\u5e76\u67094\u9879\u65b0\u9002\u5e94\u75c7\u5165\u56f4\u533b\u4fdd\u76ee\u5f55\uff0c\u5305\u62ec\u4e8c\u7ebf\u6216\u4e09\u7ebf\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u4e8c\u7ebfMSI-H\/dMMR\u5b9e\u4f53\u7624\u7b49\u3002\u81f3\u6b64\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e09\u5927NSCLC\u9002\u5e94\u75c7\u5df2\u5168\u9762\u7eb3\u5165\u533b\u4fdd\uff0c\u6210\u4e3a\u552f\u4e00\u5b9e\u73b0\u665a\u671fNSCLC\u533b\u4fdd\u5168\u7a0b\u8986\u76d6\u7684PD-(L)1\u6297\u4f53\u3002<\/p>\n<p>\u4e0d\u8fdb\u533b\u4fdd\u7684\u82b1\u5f0f\u6253\u6cd5<\/p>\n<p>\u4e0d\u540c\u4e8e\u524d\u51e0\u5e74\u4e3a\u8fdb\u533b\u4fdd\u4e89\u5f97\u201c\u5934\u7834\u8840\u6d41\u201d\uff0c\u5982\u4eca\u624b\u63e1PD-(L)1\u7684\u4f01\u4e1a\u5bf9\u4e8e\u533b\u4fdd\u51c6\u5165\u5df2\u6ca1\u6709\u90a3\u4e48\u70ed\u8877\uff0c\u751a\u81f3\u5eb7\u65b9\u548c\u57fa\u77f3\u7b49\u57282022\u5e74\u56fd\u8c08\u4e2d\u9009\u62e9\u6218\u7565\u6027\u653e\u5f03\u533b\u4fdd\u3002<\/p>\n<p>\u8fd9\u4e5f\u4e0d\u96be\u7406\u89e3\uff0c\u5728\u7ade\u4e89\u5bf9\u624b\u5982\u4e91\u7684PD-(L)1\u5e02\u573a\uff0c\u6709\u7684\u4f01\u4e1a\u4e3a\u4e86\u5206\u5f97\u4e00\u676f\u7fb9\u5df2\u7ed9\u51fa\u4f4e\u5b9a\u4ef7\uff0c\u82e5\u518d\u7ecf\u5386\u201c\u7075\u9b42\u780d\u4ef7\u201d\u52bf\u5fc5\u5143\u6c14\u5927\u4f24\u3002\u884c\u4e1a\u9f99\u5934\u6052\u745e\u3001\u4fe1\u8fbe\u548c\u541b\u5b9e\u8fdb\u533b\u4fdd\u540e\u524d\u666f\u4e5f\u4e0d\u660e\u6717\uff0c\u66f4\u9051\u8bba\u9519\u5931\u8fdb\u9662\u5148\u673a\u7684\u540e\u6765\u8005\u3002\u518d\u52a0\u4e0a\uff0c\u8d44\u672c\u5bd2\u51ac\u9020\u6210\u878d\u8d44\u56f0\u5883\uff0c\u800c\u8fd9\u4e9b\u836f\u4f01\u57fa\u672c\u90fd\u5904\u4e8e\u4e8f\u635f\u72b6\u6001\uff0cPD-(L)1\u4ea7\u54c1\u53c8\u5927\u591a\u662f\u5176\u9996\u6b3e\u5546\u4e1a\u5316\u81ea\u7814\u4ea7\u54c1\uff0c\u56e0\u6b64\uff0c\u5b83\u4eec\u6025\u9700PD-(L)1\u4ea7\u54c1\u5b8c\u6210\u81ea\u6211\u8f93\u8840\uff0c\u76ee\u524d\u4f3c\u4e4e\u5e76\u4e0d\u5341\u5206\u9002\u5408\u8d70\u957f\u671f\u7684\u533b\u4fdd\u653b\u575a\u6218\u3002<\/p>\n<p>\u8fd8\u6709\u4e00\u4e9b\u5185\u542b\u5dee\u5f02\u5316\u8bbe\u8ba1\u7684PD-(L)1\u4ea7\u54c1\u62e5\u6709\u4e0d\u8fdb\u533b\u4fdd\u7684\u5e95\u6c14\uff0c\u5728\u67d0\u79cd\u7ef4\u5ea6\u4e0a\u53ef\u4ee5\u6ee1\u8db3\u60a3\u8005\u7684\u4e2a\u6027\u5316\u9700\u6c42\uff0c\u5177\u6709\u4e00\u5b9a\u7684\u4e0d\u53ef\u66ff\u4ee3\u6027\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u4ea7\u54c1\u591a\u4ee5\u5c0f\u9002\u5e94\u75c7\u5b9e\u73b0\u5feb\u901f\u4e0a\u5e02\uff0c\u56e0\u6b64\u836f\u4f01\u5728\u505a\u533b\u4fdd\u51b3\u7b56\u65f6\u8fd8\u9700\u8981\u4ece\u4ea7\u54c1\u7684\u5168\u751f\u547d\u5468\u671f\u53bb\u505a\u5177\u4f53\u8003\u91cf\uff0c\u5305\u62ec\u5927\u9002\u5e94\u75c7\u7684\u62d3\u5c55\u3001\u66f4\u591a\u7684\u7ec4\u5408\u8054\u7528\u4ee5\u53ca\u540e\u7eed\u7684\u5e02\u573a\u6e17\u900f\u3002<\/p>\n<p>\u5bf9\u4e8e\u5916\u4f01\u800c\u8a00\uff0c\u4e0d\u8fdb\u533b\u4fdd\u5219\u662f\u7edf\u7b79\u517c\u987e\u7684\u5168\u5c40\u8c0b\u7565\uff0c\u56e0\u4e3a\u5b83\u4eec\u7684\u76ee\u6807\u5e02\u573a\u8f90\u5c04\u5168\u7403\uff0c\u4e2d\u56fd\u5730\u533a\u53ea\u662f\u5176\u4e2d\u4e00\u90e8\u5206\u3002\u663e\u800c\u6613\u89c1\uff0c\u4e2d\u56fd\u533aPD-(L)1\u9500\u552e\u60c5\u51b5\u5e76\u6ca1\u6709\u597d\u5230\u5916\u4f01\u613f\u610f\u4ee5\u7834\u574f\u5168\u7403\u5b9a\u4ef7\u7cfb\u7edf\u4e3a\u4ee3\u4ef7\u8fdb\u5165\u533b\u4fdd\u3002\u7ed3\u5408\u4e2d\u56fd\u7684\u5e02\u573a\u7ade\u4e89\u683c\u5c40\uff0c\u5b83\u4eec\u4e5f\u4f5c\u51fa\u4e86\u79ef\u6781\u5e94\u5bf9\uff0c\u56e0\u5730\u5236\u5b9c\u5730\u5347\u7ea7\u60a3\u8005\u63f4\u52a9\u9879\u76ee\uff0c\u5c06\u4ea7\u54c1\u5e74\u6cbb\u7597\u8d39\u7528\u63a7\u5236\u5728\u51e0\u4e07\u6216\u5341\u51e0\u4e07\u4e0d\u7b49\u3002<\/p>\n<p>\u5f53\u7136\uff0c\u73b0\u5728\u4e0d\u8fdb\u533b\u4fdd\u5e76\u4e0d\u4ee3\u8868\u4ee5\u540e\u4e0d\u4f1a\u9009\u62e9\u533b\u4fdd\uff0c\u4efb\u4f55\u5e02\u573a\u7b56\u7565\u90fd\u9700\u8981\u56e0\u65f6\u56e0\u52bf\u800c\u53d8\u3002<\/p>\n<p>\u6839\u636e\u4ea7\u54c1\u7684\u521b\u65b0\u4ef7\u503c\u548c\u5e02\u573a\u9700\u6c42\uff0c\u5eb7\u65b9\u56f4\u7ed5\u6d3e\u5b89\u666e\u5229\u5355\u6297\u548c\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u8c0b\u5212\u4e86\u4e24\u5957\u4e0d\u540c\u7684\u5546\u4e1a\u6218\u672f\u3002\u9488\u5bf94875\u5143\/100mg\u7684\u6d3e\u5b89\u666e\u5229\u5355\u6297\uff0c\u5eb7\u65b9\u63a8\u51fa\u60a3\u8005\u6551\u52a9\u9879\u76ee\u4f7f2\u5e74\u6cbb\u7597\u8d39\u7528\u63a7\u5236\u57283.9\u4e07\u5143\uff0c\u6bcf\u5e74\u4e0d\u52302\u4e07\u5143\u7684\u6cbb\u7597\u8d39\u7528\u6bd4\u533b\u4fdd\u5185\u201c\u56db\u5c0f\u9f99\u201d3-5\u4e07\u5143\uff08\u672a\u8ba1\u62a5\u9500\uff09\u7684\u5e74\u8d39\u7528\u66f4\u53cb\u597d\u3002\u9664\u4e86\u4f4e\u4ef7\u4f18\u52bf\uff0c\u5eb7\u65b9\u8fd8\u4e0e\u6b63\u5927\u5929\u6674\u7ed3\u76df\uff0c\u501f\u52a97000\u4f59\u540d\u9500\u552e\u94c1\u519b\u7684\u529b\u91cf\u6765\u63a8\u8fdb\u6d3e\u5b89\u666e\u5229\u5355\u6297\u5e02\u573a\u5f00\u62d3\u3002<\/p>\n<p>\u5bf9\u4e8e\u66f4\u770b\u91cd\u7684\u5361\u5ea6\u5c3c\u5229\u5355\u6297\uff0c\u5eb7\u65b9\u5728\u4e3b\u6253\u8d60\u836f\u7684\u57fa\u7840\u4e0a\u5168\u6743\u64cd\u5200\u5e02\u573a\u63a8\u5e7f\u3002\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u7684\u4ef7\u683c\u5b9a\u4e3a13220\u5143\/125mg\uff0c\u7ed3\u5408\u60a3\u8005\u6551\u52a9\u65b9\u6848\uff0c\u5176\u5e74\u6cbb\u7597\u8d39\u7528\u5e76\u4e0d\u4fbf\u5b9c\uff0c\u7ea6\u4e3a19.8\u4e07\u5143\u3002\u5eb7\u65b9\u4e4b\u6240\u4ee5\u6562\u5728\u62e5\u6324\u7684PD-(L)1\u5e02\u573a\u4e0a\u653e\u5f03\u4f4e\u4ef7\u8fd9\u5f20\u724c\uff0c\u4e0d\u4ec5\u662f\u56e0\u4e3a\u5361\u5ea6\u5c3c\u5229\u5355\u6297FIC\u7684\u5934\u8854\uff0c\u66f4\u6e90\u4e8e\u5b83\u7684\u5dee\u5f02\u5316\u4ef7\u503c\u3002<\/p>\n<p>\u4e00\u65b9\u9762\uff0c\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u540c\u65f6<a href=\"https:\/\/www.medsci.cn\/search?q=%E7%B2%BE%E5%87%86\">\u7cbe\u51c6<\/a>\u9776\u5411PD-1\u548cCTLA-4\u4e24\u4e2a\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u514d\u75ab\u68c0\u67e5\u70b9\uff0c\u534f\u540c\u53d1\u6325\u4e86\u4e24\u8005\u5e7f\u8c31\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u800c\u4e14\u53cc\u6297\u7684\u4f5c\u7528\u5f62\u5f0f\u663e\u8457\u964d\u4f4e\u4e24\u79cd\u5355\u6297\u8054\u5408\u6cbb\u7597\u96be\u4ee5\u514b\u670d\u7684\u6bd2\u6027\u53cd\u5e94\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u65a9\u83b7\u7684\u5bab\u9888\u764c\u9002\u5e94\u75c7\u5b58\u5728\u8f83\u5927\u7684\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\uff0c\u800c\u56fd\u5185\u4ec5\u6709\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u4e24\u6b3e\u5927\u5206\u5b50\u836f\u7269\u83b7\u6279\u6cbb\u7597\u5bab\u9888\u764c\uff0c\u7ade\u4e89\u683c\u5c40\u826f\u597d\u3002\u4e0d\u8fc7\uff0c\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u4eae\u773c\u7684\u9500\u552e\u6210\u7ee9\u80cc\u540e\u4ea6\u6709\u8d85\u9002\u5e94\u75c7\u5e94\u7528\u7684\u56e0\u7d20\u3002<\/p>\n<p>\u4e3a\u4e86\u5145\u5206\u7b79\u5907\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u7684\u5546\u4e1a\u5316\uff0c\u5eb7\u65b9\u81ea2020\u5e74\u5e95\u5373\u5f00\u59cb\u62db\u5175\u4e70\u9a6c\uff0c\u73b0\u5df2\u6253\u9020\u51fa\u4e00\u652f\u6df1\u8c19\u533b\u5b66\u7684\u7cbe\u9510\u9500\u552e\u961f\u4f0d\uff0c\u5176\u89c4\u6a21\u4e3a652\u4eba\u3002\u4e4b\u540e\uff0c\u5eb7\u65b9\u76f8\u7ee7\u4e0e\u534e\u6da6\u533b\u836f\u548c\u5e7f\u5dde\u533b\u836f\u7b49\u533b\u836f\u6d41\u901a\u4f01\u4e1a\u8fbe\u6210\u5408\u4f5c\uff0c\u5b9e\u73b0\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u66f4\u5e7f\u6cdb\u7684\u9500\u552e\u6e20\u9053\u8986\u76d6\u3002\u591a\u65b9\u4f4d\u5e03\u5c40\u4e4b\u4e0b\uff0c\u5eb7\u65b9\u7684\u9500\u552e\u652f\u51fa\u81ea\u662f\u6c34\u6da8\u8239\u9ad8\uff0c\u4ece2021\u5e74\u76841.79\u4ebf\u5143\u4e0a\u7ffb\u4e09\u500d\u81f32022\u5e74\u76845.53\u4ebf\u5143\u3002<\/p>\n<p>\u4e0e\u5eb7\u65b9\u63a8\u5e7f\u5361\u5ea6\u5c3c\u5229\u5355\u6297\u7684\u601d\u8def\u7c7b\u4f3c\uff0c\u590d\u5b8f\u6c49\u9716\u4e5f\u4e3a\u65af\u9c81\u5229\u5355\u6297\u5728\u56fd\u5185\u7684\u9500\u552e\u914d\u7f6e\u4e86\u8fd1400\u4eba\u5de6\u53f3\u7684\u81ea\u5efa\u5546\u4e1a\u5316\u56e2\u961f\uff0c\u4ee5\u7cbe\u7ec6\u5316<a href=\"https:\/\/www.medsci.cn\/guideline\/list.do?q=%E7%AE%A1%E7%90%86\">\u7ba1\u7406<\/a>\u6a21\u5f0f\u89e6\u8fbe\u8fd1\u5343\u5bb6\u533b\u9662\u76842.3\u4e07\u540d\u533b\u751f\u3002\u590d\u5b8f\u6c49\u9716\u7684\u5546\u4e1a\u5316\u80fd\u529b\u6bcb\u5eb8\u7f6e\u7591\uff0c\u65e9\u5728\u591a\u6b3e\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u9500\u552e\u63a8\u5e7f\u4e2d\u5f97\u5230\u9524\u70bc\u4e0e\u8ba4\u53ef\uff0c\u65e2\u5f80\u4e30\u5bcc\u7684\u80bf\u7624\u5e02\u573a\u7ecf\u9a8c\u6c89\u6dc0\u4e5f\u6210\u4e3a\u65af\u9c81\u5229\u5355\u6297\u62a2\u5360\u5e02\u573a\u7684\u6709\u5229\u6b66\u5668\u30022023\u5e74\uff0c\u590d\u5b8f\u6c49\u9716\u518d\u8fdb\u4e00\u7a0b\uff0c\u63d0\u524d\u7ec4\u5efa<a href=\"https:\/\/ipsen2017.medsci.cn\/ipsen\/sporty\/show-details\/3074\/2\">\u6d88\u5316<\/a>\u9053\u80bf\u7624\u7ec6\u5206\u65b9\u5411\u7684\u9500\u552e\u961f\u4f0d\uff0c\u4e3a\u5373\u5c06\u83b7\u6279\u7684\u98df\u7ba1\u9cde\u764c\u9002\u5e94\u75c7\u6e17\u900f\u672a\u96e8\u7ef8\u7f2a\u3002<\/p>\n<p>\u9762\u5bf9\u5f3a\u654c\u6797\u7acb\u7684\u7ade\u4e89\u73af\u5883\uff0c\u5149\u51ed\u5f3a\u6a2a\u7684\u5e02\u573a\u9500\u552e\u63a8\u52a8\u836f\u54c1\u5546\u4e1a\u5316\u53ef\u80fd\u5728\u77ed\u671f\u5185\u4f1a\u53d6\u5f97\u4e00\u5b9a\u7684\u6218\u7ee9\uff0c\u4f46\u7edd\u975e\u957f\u8fdc\u4e4b\u8ba1\uff0c\u5f88\u96be\u83b7\u5f97\u6700\u7ec8\u7684\u80dc\u5229\u3002\u8ffd\u6839\u6eaf\u6e90\uff0c\u4ea7\u54c1\u6700\u672c\u8d28\u7684\u7ade\u4e89\u529b\u6765\u81ea\u5176\u5185\u5728\u4ef7\u503c\u3002\u65af\u9c81\u5229\u5355\u6297\u7684\u4e34\u5e8a\u4ef7\u503c\u5219\u4e3b\u8981\u4f53\u73b0\u5728\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u9002\u5e94\u75c7\u5f00\u53d1\u4e0e\u51fa\u8272\u7684\u7597\u6548\uff0c\u8fd9\u4e5f\u662f\u8fd9\u6b3e\u533b\u4fdd\u5916\u7684\u836f\u7269\u8d62\u5f97\u53ef\u89c2\u5e02\u573a\u56de\u62a5\u7684\u5173\u952e\u539f\u56e0\u3002<\/p>\n<p>III\u671fASTRUM-005\u7814\u7a76\u663e\u793a\uff0c\u65af\u9c81\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u521b\u9020\u4e86\u4e00\u7ebf\u514d\u75ab\u6cbb\u7597\u5e7f\u6cdb\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08ES-SCLC\uff09\u6700\u957f\u7684\u603b\u4eba\u7fa4\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7eaa\u5f55\uff0c\u8fbe15.8\u4e2a\u6708\uff0c\u4e0e\u6807\u51c6\u5316\u7597\u76f8\u6bd4\u5ef6\u957f\u4e864.7\u4e2a\u6708\u3002\u6b64\u524dO\u836f\u548cK\u836f\u66fe\u53cc\u53cc\u6298\u621f\u4e8eES-SCLC\uff0c\u53e6\u59163\u6b3ePD-L1\u6291\u5236\u5242\u5bf9\u6bd4\u5355\u7eaf\u5316\u7597\u4ec5\u5b9e\u73b02-2.5\u4e2a\u6708\u5de6\u53f3\u7684OS\u83b7\u76ca\uff0c\u5305\u62ec\u963f\u66ff\u5229\u73e0\u5355\u6297\u3001\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u548c\u963f\u5f97\u8d1d\u5229\u5355\u6297\u3002\u5f53\u7136\uff0c\u8fd9\u53ea\u662f\u95f4\u63a5\u4e14\u7c97\u7565\u7684\u6570\u636e\u5bf9\u6bd4\uff0c\u96be\u8bba\u9ad8\u4e0b\u3002<\/p>\n<p>\u4e3a\u4e86\u8fdb\u4e00\u6b65\u8bc1\u660e\u81ea\u8eab\u7684\u5b9e\u529b\u548c\u6253\u5f00\u66f4\u5927\u7684\u6d77\u5916\u5e02\u573a\uff0c\u65af\u9c81\u5229\u5355\u6297\u76f4\u63a5\u4e0e\u963f\u66ff\u5229\u73e0\u5355\u6297\u5c55\u5f00\u5934\u5bf9\u5934\u4e00\u6218\u3002ASTRIDE\u6865\u63a5\u7814\u7a76\u62df\u62db\u52df200\u4f8b\u7f8e\u56fdES-SCLC\u60a3\u8005\uff0c\u5e76\u5df2\u57282022\u5e7411\u6708\u5b8c\u6210\u9996\u4f8b\u53d7\u8bd5\u8005\u7ed9\u836f\u3002\u590d\u5b8f\u6c49\u9716\u8fd8\u8ba1\u5212\u4e8e2024\u5e74\u5728\u7f8e\u56fd\u9012\u4ea4\u65af\u9c81\u5229\u5355\u6297\u7684\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n<p>\u5728\u751f\u5b58\u83b7\u76ca\u663e\u8457\u6539\u5584\u7684\u524d\u63d0\u4e0b\uff0c\u65af\u9c81\u5229\u5355\u6297\u8fd8\u5177\u6709\u8f83\u5927\u7684\u4ef7\u683c\u4f18\u52bf\uff0c\u66f4\u597d\u5730\u5e73\u8861\u4e86\u60a3\u8005\u7528\u836f\u7684\u53ef\u53ca\u6027\u95ee\u9898\u3002\u8be5\u836f\u7269\u5b9a\u4ef7\u4e3a5588\u5143\/100mg\uff0c\u6148\u5584\u8d60\u836f\u9879\u76ee\u843d\u5730\u540e\uff0c2\u5e74\u6cbb\u7597\u82b1\u8d39\u7ea66.7\u4e07\u5143\uff0c\u800c\u5176\u4ed63\u6b3e\u5728\u56fd\u5185\u83b7\u6279ES-SCLC\u7684PD-L1\u7597\u6cd5\u5e74\u6cbb\u7597\u8d39\u7528\u5747\u572810\u4e07\u4ee5\u4e0a\u3002\u9664\u4e86\u8d60\u836f\u7b56\u7565\uff0c\u590d\u5b8f\u6c49\u9716\u4e5f\u79ef\u6781\u62e5\u62b1\u521b\u65b0\u652f\u4ed8\u65b9\u5f0f\uff0c\u901a\u8fc7\u57ce\u5e02\u60e0\u6c11\u4fdd\u52a0\u901f\u65af\u9c81\u5229\u5355\u6297\u5e02\u573a\u53ef\u53ca\u3002<\/p>\n<p>\u518d\u6765\u770b\u6069\u6c83\u5229\u5355\u6297\uff0c\u8be5\u836f\u7269\u7684\u4ef7\u683c\u4e3a5980\u5143\/200mg\uff0c\u901a\u8fc7\u60a3\u8005\u63f4\u52a9\u65b9\u6848\uff0c2\u5e74\u6cbb\u7597\u8d39\u7528\u5171\u7ea67.2\u4e07\u5143\u3002\u76ee\u524d\uff0c\u6069\u6c83\u5229\u5355\u6297\u6240\u5c5e\u6743\u76ca\u6d89\u53ca\u591a\u65b9\uff0c\u5eb7\u5b81\u6770\u745e\u4f5c\u4e3a\u539f\u7814\u65b9\u8d1f\u8d23\u751f\u4ea7\u548c\u8d28\u91cf\uff0c\u601d\u8def\u8fea\u628a\u63a7\u80bf\u7624\u9886\u57df\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u6b4c\u793c\u5f00\u5c55\u75c5\u6bd2\u6027\u75be\u75c5\u9886\u57df\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\uff0c\u5148\u58f0\u627f\u63a5\u4e2d\u56fd\u5927\u9646\u7684\u72ec\u5bb6\u5546\u4e1a\u63a8\u5e7f\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5148\u58f0\u8fd8\u662f\u601d\u8def\u8fea\u7684\u80a1\u4e1c\uff0c\u5982\u6b64\u6df1\u5ea6\u6346\u7ed1\u7684\u5173\u7cfb\u4f7f\u5f97\u5408\u4f5c\u66f4\u4e3a\u7d27\u5bc6\u3002<\/p>\n<p>\u6069\u6c83\u5229\u5355\u6297\u51ed\u501f\u4e8c\u7ebf\u53ca\u4ee5\u4e0aMSI-H\u6216dMMR\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\u83b7\u6279\u4e0a\u5e02\uff0c\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u53ef\u76ae\u4e0b\u6ce8\u5c04\u7684PD-L1\u5355\u6297\uff0c\u8fd9\u662f\u5eb7\u5b81\u6770\u745e\u548c\u601d\u8def\u8fea\u7684\u5feb\u901f\u63a8\u8fdb\u7684\u6210\u679c\uff1b\u800c\u6069\u6c83\u5229\u5355\u6297\u5e74\u95005\u4ebf\u591a\u5143\u3001\u60e0\u53ca\u7ea62\u4e07\u60a3\u8005\u7684\u6210\u7ee9\u5219\u79bb\u4e0d\u5f00\u5148\u58f0\u7684\u8d21\u732e\u3002<\/p>\n<p>\u6210\u7acb\u4e8e1995\u5e74\u7684\u5148\u58f0\u62e5\u6709\u6210\u719f\u7684\u63a8\u5e7f\u7ecf\u9a8c\uff0c\u5176\u9500\u552e\u56e2\u961f\u89c4\u6a21\u7eb5\u7136\u65e0\u6cd5\u5339\u654c\u6052\u745e\uff0c\u4f46\u4ecd\u8fdc\u8d85\u5927\u90e8\u5206\u836f\u4f01\uff0c2022\u5e74\u5176\u8425\u9500\u4eba\u5458\u5df2\u8fbe5000\u5de6\u53f3\u3002\u8fd1\u51e0\u5e74\uff0c\u5148\u58f0\u5927\u529b\u8f6c\u578b\u521b\u65b0\u3001\u53d1\u5c55\u80bf\u7624\u4e1a\u52a1\u7684\u8def\u7ebf\u4f7f\u4e4b\u6210\u4e3a\u4e86\u6bd4\u8f83\u9002\u5408\u63a8\u5e7f\u6069\u6c83\u5229\u5355\u6297\u7684\u5e73\u53f0\uff0c\u540c\u65f6\u5148\u58f0\u4e5f\u9700\u8981\u501f\u52a9\u6069\u6c83\u5229\u5355\u6297\u6765\u8fdb\u4e00\u6b65\u5265\u79bb\u5176\u4f20\u7edf\u836f\u4f01\u7684\u6807\u7b7e\u3002<\/p>\n<p>\u5c0f\u7ed3<\/p>\n<p>\u867d\u7136\u4e2d\u56fdPD-(L)1\u5e02\u573a\u9884\u671f\u9ad8\u5f00\u4f4e\u8d70\uff0c\u4f46\u662f\u4ee5\u6b64\u4e3a\u8d77\u70b9\uff0c\u4e2d\u56fd\u521b\u65b0\u836f\u5b8c\u6210\u4ece0\u52301\u7684\u7834\u51b0\u3002\u4e0d\u5c11\u4f01\u4e1a\u6293\u4f4f\u65f6\u673a\uff0c\u5728\u5feb\u901f\u8ddf\u968f\u7684\u8fc7\u7a0b\u91cc\u9010\u6b65\u6253\u901a\u4e86\u521b\u65b0\u836f\u5f00\u53d1\u7684\u5404\u4e2a\u5173\u8282\uff0c\u5e76\u4e0d\u65ad\u8fdb\u5316\u5b9e\u73b0\u4ecebiotech\u5230biopharma\u7684\u8dc3\u8fc1\u3002<\/p>\n<p>\u5173\u4e8ePD-(L)1\u7684\u6545\u4e8b\u8fd8\u5728\u7ee7\u7eed\u4e66\u5199\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u56fd\u4ea7PD-(L)1\u5df2\u6562\u4e8e\u5934\u5bf9\u5934\u6311\u6218\u6807\u6746\u7597\u6cd5\uff1b\u836f\u4f01\u7eb7\u7eb7\u5f00\u542f\u6d77\u5916\u5f81\u9014\uff0c\u51fa\u6d77\u65b9\u5411\u4e5f\u4e0d\u4ec5\u9650\u4e8e\u7f8e\u56fd\uff1b\u540c\u65f6\u56f4\u7ed5PD-(L)1\u8fdb\u884c\u8fed\u4ee3\u5e03\u5c40\uff0c\u591a\u6b3e\u6280\u672f\u542b\u91cf\u66f4\u9ad8\u7684\u76ae\u4e0b\u5236\u5242\u3001\u53cc\u6297\u548c\u6297\u4f53\u878d\u5408\u86cb\u767d\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u2026\u2026<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u521b\u65b0\u836f\u7684\u4e16\u754c\u91cc\uff0cPD-(L)1\u836f\u7269\u582a\u79f0\u73b0\u8c61\u7ea7\u4ea7\u54c1\u3002\u5b83\u901a\u8fc7\u6291\u5236\u80bf\u7624\u514d\u75ab\u9003\u9038\u673a\u5236\u98a0\u8986\u4f20\u7edf\u80bf\u7624\u6cbb\u7597\u8303\u5f0f\uff0c\u4e0d\u4ec5\u9769\u65b0\u4e86\u80ba\u764c\u3001\u809d\u764c\u548c\u80c3\u764c\u7b49\u5e38\u89c1\u764c\u79cd\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u4e5f\u586b\u8865\u4e86Merkel\u7ec6\u80de\u7624\u548c\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\u7b49\u7f55\u89c1\u7624 \u5728\u521b\u65b0\u836f\u7684\u4e16\u754c\u91cc\uff0cPD-(L)1\u836f\u7269\u582a [&hellip;]<\/p>\n<span><a href=\"https:\/\/www.dbpharm.net\/index.php\/2023\/06\/21\/building-your-personal-brand\/\">More...<\/a><\/span>","protected":false},"author":1,"featured_media":285,"comment_status":"closed","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":[],"categories":[18],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/posts\/262"}],"collection":[{"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/comments?post=262"}],"version-history":[{"count":2,"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/posts\/262\/revisions"}],"predecessor-version":[{"id":349,"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/posts\/262\/revisions\/349"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/media\/285"}],"wp:attachment":[{"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/media?parent=262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/categories?post=262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dbpharm.net\/index.php\/wp-json\/wp\/v2\/tags?post=262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}